Associations of autozygosity with a broad range of human phenotypes.
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Tregouet D-A., Tuomi T., Vollenweider P., Wang CA., Weir DR., Whitfield JB., Wijmenga C., Wong T-Y., Wright J., Yang J., Yu L., Zemel BS., Zonderman AB., Perola M., Magnusson PKE., Uitterlinden AG., Kooner JS., Chasman DI., Loos RJF., Franceschini N., Franke L., Haley CS., Hayward C., Walters RG., Perry JRB., Esko T., Helgason A., Stefansson K., Joshi PK., Kubo M., Wilson JF.
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p ROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44-66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.