During her postdoctoral studies with Karen Duff at Columbia University and at the UK Dementia Research Institute at UCL, Steph's work on pathological tau species led to the discovery that seed-competent tau filaments are tethered within secreted extracellular vesicles isolated from Alzheimer’s Disease brain.
Using a variety of proteomic and cryo-electron microscopy imaging techniques, Steph's research will focus on determining the molecular tethers/mechanisms of aberrant tau interaction with intracellular and secreted membrane compartments. She will investigate how assembled tau species induce cellular pathology in Alzheimer's Disease and other tauopathies.