Luigi Celauro
Postdoctoral Research Scientist
Luigi holds a master’s degree in Molecular and Cellular Biology from University of Bologna (Italy), where he was involved in a project aiming at understanding the molecular mechanisms and epigenetic modifications occurring in a rare neurodevelopmental disorder known as AGC1 deficiency.
In 2023 Luigi earned a PhD in Molecular Biology from the International School for Advanced Studies (SISSA, Italy) in the laboratory of Professor Giuseppe Legname for his work on prions and their interaction with tau amyloid fibrils. Throughout his PhD, he conducted extensive research on the production of recombinant proteins and amyloid fibrils. By combining these tools with prion-infected cell lines, he was able to explore the interplay between these two pathological proteins in the context of neurodegenerative diseases.
As Post-Doctoral Scientist at SISSA, Luigi investigated the aggregation of TDP-43, aiming at developing a new diagnostic tool for neurodegenerative diseases involving the aggregation of this protein.
In October 2024, Luigi joined Steph Fowler's group as a Postdoctoral Research Scientist, where he will investigate neuronal alterations caused by the pathological aggregation of tau in an iPSC-derived model of tauopathy using spatial proteomics.
Recent publications
Seeded aggregation of TDP-43 induces its loss of function and reveals early pathological signatures
Journal article
Scialò C. et al, (2025), Neuron, 113, 1614 - 1628.e11
The Cellular Prion Protein as Universal Receptor for Amyloid Proteins
Chapter
Celauro L. and Legname G., (2025), 411 - 434
Unfolding Mechanism and Fibril Formation Propensity of Human Prion Protein in the Presence of Molecular Crowding Agents
Journal article
Madheswaran M. et al, (2024), International Journal of Molecular Sciences, 25, 9916 - 9916
Transmission of Norwegian reindeer CWD to sheep by intracerebral inoculation results in an unusual phenotype and prion distribution
Journal article
Harpaz E. et al, (2024), Veterinary Research, 55
Tau seeding activity in skin biopsy differentiates tauopathies from synucleinopathies
Journal article
Dellarole IL. et al, (2024), npj Parkinson's Disease, 10