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The aetiology of the ampicillin rash is uncertain although numerous theories have been proposed--mainly immunological. One such concerns the presence of anti-epithelial antibodies which have received conflicting reports in the literature. In this study, skin biopsies from three patients with a maculopapular ampicillin-rash were studied by immunofluorescence to investigate the presence of anti-epithelial antibodies. However immunofluorescence for IgG, IgM, IgA and C3 was completely negative so that we were unable to provide any support for this particular hypothesis.

Original publication

DOI

10.1111/j.1365-2222.1982.tb02528.x

Type

Journal article

Journal

Clinical allergy

Publication Date

05/1982

Volume

12

Pages

279 - 280

Keywords

Epidermis, Lymphocytes, Histiocytes, Humans, Drug Eruptions, Edema, Ampicillin, Fluorescent Antibody Technique