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The aetiology of the ampicillin rash is uncertain although numerous theories have been proposed--mainly immunological. One such concerns the presence of anti-epithelial antibodies which have received conflicting reports in the literature. In this study, skin biopsies from three patients with a maculopapular ampicillin-rash were studied by immunofluorescence to investigate the presence of anti-epithelial antibodies. However immunofluorescence for IgG, IgM, IgA and C3 was completely negative so that we were unable to provide any support for this particular hypothesis.

Original publication




Journal article


Clinical allergy

Publication Date





279 - 280


Epidermis, Lymphocytes, Histiocytes, Humans, Drug Eruptions, Edema, Ampicillin, Fluorescent Antibody Technique