Ets, Ap‐1 and GATA factor families regulate the utrophin B promoter: potential regulatory mechanisms for endothelial‐specific expression
Perkins KJ., Davies KE.
Duchenne muscular dystrophy is caused by dystrophin deficiency, which can be prevented in the mdx mouse model by over‐expression of an autosomal homologue, utrophin. Utrophin has two characterised full‐length promoters, A and B. No data are available on the transcriptional regulation of B utrophin, which has been recently localised to the endothelium. Similar to characterised endothelial promoters, Ets and Ap‐1 individually trans‐activate the human B core promoter. Synergistic activation by GATA‐2 and c‐jun to the order of 20‐fold was observed.