Immune checkpoint blockade sensitivity and progression-free survival associates with baseline CD8
            +
            T cell clone size and cytotoxicity

Watson RA.; Tong O.; Cooper R.; Taylor CA.; Sharma PK.; de los Aires AV.; Mahé EA.; Ruffieux H.; Nassiri I.; Middleton MR.; Fairfax BP.

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Immune checkpoint blockade sensitivity and progression-free survival associates with baseline CD8 + T cell clone size and cytotoxicity

Watson RA., Tong O., Cooper R., Taylor CA., Sharma PK., de los Aires AV., Mahé EA., Ruffieux H., Nassiri I., Middleton MR., Fairfax BP.

The cytotoxicity and clone size of CD8 + T cell pretreatment are prognostic for immune checkpoint blockade.

Original publication

DOI

10.1126/sciimmunol.abj8825

Type

Journal article

Journal

Science Immunology

Publisher

American Association for the Advancement of Science (AAAS)

Publication Date

29/10/2021