Risk of Psychiatric Illness From Advanced Paternal Age Is Not Predominantly From De Novo Mutations
Gratten J., Wray NR., Peyrot WJ., McGrath JJ., Visscher PM., Goddard ME.
(Abstracted from Nat Genet 2016;48:718–724) Epidemiologic studies have reported an increased risk of schizophrenia, autism, and other psychiatric disorders among offspring of older fathers. It is widely assumed that paternal age–related de novo mutations are the primary underlying causal mechanism.