The potassium–chloride cotransporter 2 promotes cervical cancer cell migration and invasion by an ion transport‐independent mechanism
Wei W., Akerman CJ., Newey SE., Pan J., Clinch NWV., Jacob Y., Shen M., Wilkins RJ., Ellory JC.
Non‐Technical Summary K+–Cl− cotransporters (KCCs) play a fundamental role in epithelial cell function, both in the context of ionic homeostasis and also in cell morphology, cell division and locomotion. Unlike other ubiquitously expressed KCC isoforms, expression of KCC2 is widely considered to be restricted to neurons. Here we report a novel finding that KCC2 is widely expressed in several human cancer cell lines including the cervical cancer cell line (SiHa). Our data establish that KCC2 expression and function is not restricted to neurons and that KCC2 serves to increase cervical cancer progression via an ion transport‐independent mechanism.