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Abstract  Microvasculitis may play a greater part in the pathogenesis of paraproteinaemic neuropathies than is generally recognised, producing tissue destruction by convergent immune and physical mechanisms. We present a patient with a clinical syndrome of mononeuritis multiplex and a circulating IgM lambda paraprotein, in whom bone marrow aspiration revealed a lymphoplasmacytoid lymphoma. Microvasculitic changes were present in the first nerve biopsy, and the second showed extensive destruction of neural architecture and deposition of IgM‐related material. A 2‐stage pathogenic cascade is postulated and explored with a review of the relevant literature.

Original publication

DOI

10.1046/j.1529-8027.2003.03013.x

Type

Journal article

Journal

Journal of the Peripheral Nervous System

Publisher

Wiley

Publication Date

06/2003

Volume

8

Pages

100 - 107