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The Virtual Physiological Human (VPH) project aims to develop integrative, explanatory and predictive computational models (C-Models) as numerical investigational tools to study disease, identify and design effective therapies and provide anin silicoplatform for drug screening. Ultimately, these models rely on the analysis and integration of experimental data. As such, the success of VPH depends on the availability of physiologically realistic experimental models (E-Models) of human organ function that can be parametrized to test the numerical models. Here, the current state of suitable E-models, ranging fromin vitronon-human cell organelles toin vivohuman organ systems, is discussed. Specifically, challenges and recent progress in improving the physiological realism of E-models that may benefit the VPH project are highlighted and discussed using examples from the field of research on cardiovascular disease, musculoskeletal disorders, diabetes and Parkinson's disease.

Original publication

DOI

10.1098/rsfs.2015.0076

Type

Journal article

Journal

Interface Focus

Publisher

The Royal Society

Publication Date

06/04/2016

Volume

6

Pages

20150076 - 20150076