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AbstractThe microtubule‐associated protein tau is integral to neuronal process development and has a role in the pathogenesis of several neurodegenerative conditions. We examined possible roles for tau in cultured oligodendrocyte process formation by using antisense oligonucleotide treatment. Inhibition of tau synthesis with single oligonucleotides resulted in decreased tau protein levels and significantly shorter cellular processes. Simultaneous use of two nonoverlapping oligonucleotides caused a major reduction in tau levels and severely inhibited process outgrowth. The timing of oligonucleotide addition to oligodendrocyte cultures was important, with addition of antisense at the time of plating into culture having the most significant effect on morphology through reduction of tau expression. © 2008 Wiley‐Liss, Inc.

Original publication

DOI

10.1002/jnr.21719

Type

Journal article

Journal

Journal of Neuroscience Research

Publisher

Wiley

Publication Date

09/2008

Volume

86

Pages

2591 - 2601