Contact information
Research groups
Colleges
Elizabeth Dellar
DPhil MBiolSci
Postdoctoral Researcher
Biography
I graduated with an MBiolSci in Molecular Biology from the University of Sheffield, during which I worked on several neurodegenerative diseases, firstly at Sheffield Institute for Translational Neuroscience (SITraN), and then in industry at Eli Lilly in Surrey. In 2016 I joined the Oxford Interdisciplinary Bioscience Programme, where my DPhil research used Drosophila as a model system to investigate RNA cargo packaging into extracellular vesicles (EVs) under normal and oxidative stress conditions.
Research Summary
My research is centred on biomarker discovery for the neurodegenerative disease amyotrophic lateral sclerosis (ALS). This involves proteomic profiling of cerebrospinal fluid from patients and asymptomatic carriers of disease-causing C9orf72 variant in ALS. I have a particular focus on extracellular vesicles (EVs), derived from biofluids, induced pluripotent stem cells and post mortem tissue, as a source of potential new biomarkers in neurodegenerative diseases.
Key publications
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Elevated Cerebrospinal Fluid Ubiquitin Carboxyl‐Terminal Hydrolase Isozyme L1 in Asymptomatic C9orf72 Hexanucleotide Repeat Expansion Carriers
Journal article
Dellar ER. et al, (2024), Annals of Neurology
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Data‐independent acquisition proteomics of cerebrospinal fluid implicates endoplasmic reticulum and inflammatory mechanisms in amyotrophic lateral sclerosis
Journal article
Dellar ER. et al, (2024), Journal of Neurochemistry, 168, 115 - 127
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Oxidative stress‐induced changes in the transcriptomic profile of extracellular vesicles
Journal article
Dellar ER. et al, (2024), Journal of Extracellular Biology, 3
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Unpacking extracellular vesicles: RNA cargo loading and function
Journal article
Dellar ER. et al, (2022), Journal of Extracellular Biology, 1