Sally Cowley

Sally is a Wellcome Trust Career Re-Entry Fellow, engaged in a program of research into the differentiation of human Embryonic Stem (hES) cells along the myeloid pathway. She has set up (with William James) and is Head of the James and Lillian Martin Centre for Stem Cell Research within the Sir William Dunn School of Pathology, University of Oxford (affiliated to the Oxford Stem Cell Institute) for work with hES cells and human induced Pluripotent Stem cells (iPSc). She supervises collaborative projects within this Facility, including: the differentiation of iPSc from Chronic Granulomatous Disease patients into macrophages, (CGD Research Trust); the generation of iPSc from people with Parkinson's  (Oxford Parkinson's Disease Centre, Parkinson’s UK).

Induced Pluripotent Stem cells (iPSC) derived from patients with genetic disease offers a new, hugely exciting opportunity to model human diseases in vitro. iPSC are particularly important for modelling neurological conditions, where patient material is generally unavailable until after death, and for rare genetic disorders, where patient material is severely limiting.

To harness this potential, I have established and am Head of the James and Lillian Martin Centre for Stem Cell Research (within the Sir William Dunn School of Pathology, University of Oxford, and part of the Oxford Stem Cell Institute), with particular interests in the use of iPSC for modelling disease, and expertise in human iPSC derivation, genetic modification, and differentiation to myeloid and neuronal lineages.